ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein lin-9 homolog

Intermolecular
Cysteine 122 and cysteine 119 of Protein lin-37 homolog
Intramolecular
Cysteine 143 and cysteine 145
A redox-regulated disulphide may form between cysteine 122 of Protein lin-9 homolog and cysteine 119 of Protein lin-37 homolog.

Details

Redox score ?
66
PDB code
7n40
Structure name
crystal structure of lin9-rbap48-lin37, a muvb subcomplex
Structure deposition date
2021-06-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
100
Peptide A name
Protein lin-9 homolog
Peptide B name
Protein lin-37 homolog
Peptide A accession
Q5TKA1
Peptide B accession
Q96GY3
Peptide A residue number
122
Peptide B residue number
119

Ligandability

Cysteine 122 of Protein lin-9 homolog

Cysteine 119 of Protein lin-37 homolog

A redox-regulated disulphide may form within Protein lin-9 homolog between cysteines 143 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7r1d
Structure name
structure of muvb complex
Structure deposition date
2022-02-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
56
Minimum pKa ?
9
% buried
44
Peptide accession
Q5TKA1
Residue number A
143
Residue number B
145
Peptide name
Protein lin-9 homolog

Ligandability

Cysteine 143 of Protein lin-9 homolog

Cysteine 145 of Protein lin-9 homolog

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