ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein angel homolog 2

Intramolecular
Cysteine 241 and cysteine 257
Cysteine 217 and cysteine 349
Cysteine 305 and cysteine 344
Cysteine 217 and cysteine 257
Cysteine 190 and cysteine 470
Cysteine 217 and cysteine 254
A redox-regulated disulphide may form within Protein angel homolog 2 between cysteines 241 and 257.

Details

Redox score ?
72
PDB code
6rvz
Structure name
crystal structure of angel2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate
Structure deposition date
2019-06-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5VTE6
Residue number A
241
Residue number B
257
Peptide name
Protein angel homolog 2

Ligandability

Cysteine 241 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein angel homolog 2 between cysteines 217 and 349.

Details

Redox score ?
68
PDB code
6rvz
Structure name
crystal structure of angel2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate
Structure deposition date
2019-06-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
97
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5VTE6
Residue number A
217
Residue number B
349
Peptide name
Protein angel homolog 2

Ligandability

Cysteine 217 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 349 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein angel homolog 2 between cysteines 305 and 344.

Details

Redox score ?
60
PDB code
6rvz
Structure name
crystal structure of angel2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate
Structure deposition date
2019-06-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5VTE6
Residue number A
305
Residue number B
344
Peptide name
Protein angel homolog 2

Ligandability

Cysteine 305 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 344 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein angel homolog 2 between cysteines 217 and 257. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6rvz
Structure name
crystal structure of angel2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate
Structure deposition date
2019-06-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
97
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5VTE6
Residue number A
217
Residue number B
257
Peptide name
Protein angel homolog 2

Ligandability

Cysteine 217 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 257 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein angel homolog 2 between cysteines 190 and 470. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6rw0
Structure name
crystal structure of angel2, a 2',3'-cyclic phosphatase
Structure deposition date
2019-06-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
57
Peptide accession
Q5VTE6
Residue number A
190
Residue number B
470
Peptide name
Protein angel homolog 2

Ligandability

Cysteine 190 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 470 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein angel homolog 2 between cysteines 217 and 254. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6rw0
Structure name
crystal structure of angel2, a 2',3'-cyclic phosphatase
Structure deposition date
2019-06-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
93
Minimum pKa ?
13
% buried
100
Peptide accession
Q5VTE6
Residue number A
217
Residue number B
254
Peptide name
Protein angel homolog 2

Ligandability

Cysteine 217 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 254 of Protein angel homolog 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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