a tool for identifying drug-targetable redox-active disulphides

Rho guanine nucleotide exchange factor 16

Intramolecular

Cysteine 382 and cysteine 469

A redox-regulated disulphide may form within Rho guanine nucleotide exchange factor 16 between cysteines 382 and 469.

Details

Redox score ?

66

PDB code

Structure name

structure of ephexin4 idpsh

Structure deposition date

2020-08-15

Thiol separation (Å)

4

Half-sphere exposure sum ?

73

Minimum pK_a ?

9

% buried

96

Peptide accession

Residue number A

382

Residue number B

469

Peptide name

Rho guanine nucleotide exchange factor 16

Ligandability

Cysteine 382 of Rho guanine nucleotide exchange factor 16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 469 of Rho guanine nucleotide exchange factor 16

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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