ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Deubiquitinase MYSM1

Intramolecular
Cysteine 440 and cysteine 445 L
Cysteine 423 and cysteine 463
A redox-regulated disulphide may form within Deubiquitinase MYSM1 between cysteines 440 and 445 (81 and 86 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2dce
Structure name
solution structure of the swirm domain of human kiaa1915 protein
Structure deposition date
2006-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
19
Peptide accession
Q5VVJ2
Residue number A
440
Residue number B
445
Peptide name
Deubiquitinase MYSM1

Ligandability

Cysteine 440 of Deubiquitinase MYSM1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 445 of Deubiquitinase MYSM1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Deubiquitinase MYSM1 between cysteines 423 and 463 (64 and 104 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
2dce
Structure name
solution structure of the swirm domain of human kiaa1915 protein
Structure deposition date
2006-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
7
Peptide accession
Q5VVJ2
Residue number A
423
Residue number B
463
Peptide name
Deubiquitinase MYSM1

Ligandability

Cysteine 423 of Deubiquitinase MYSM1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 463 of Deubiquitinase MYSM1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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