ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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BRO1 domain-containing protein BROX

Intramolecular
Cysteine 267 and cysteine 323
Cysteine 255 and cysteine 323
A redox-regulated disulphide may form within BRO1 domain-containing protein BROX between cysteines 267 and 323.

Details

Redox score ?
64
PDB code
3r9m
Structure name
crystal structure of the brox bro1 domain
Structure deposition date
2011-03-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
40
Peptide accession
Q5VW32
Residue number A
267
Residue number B
323
Peptide name
BRO1 domain-containing protein BROX

Ligandability

Cysteine 267 of BRO1 domain-containing protein BROX

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of BRO1 domain-containing protein BROX

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within BRO1 domain-containing protein BROX between cysteines 255 and 323. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
3um3
Structure name
crystal structure of the brox bro1 domain in complex with the c- terminal tail of chmp4b
Structure deposition date
2011-11-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
75
Peptide accession
Q5VW32
Residue number A
255
Residue number B
323
Peptide name
BRO1 domain-containing protein BROX

Ligandability

Cysteine 255 of BRO1 domain-containing protein BROX

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of BRO1 domain-containing protein BROX

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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