ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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N-alpha-acetyltransferase 35, NatC auxiliary subunit

Intramolecular
Cysteine 112 and cysteine 115
Cysteine 114 and cysteine 115
Cysteine 112 and cysteine 114
Cysteine 112 and cysteine 157
A redox-regulated disulphide may form within N-alpha-acetyltransferase 35, NatC auxiliary subunit between cysteines 112 and 115. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7mx2
Structure name
cryo-em structure of human ternary natc complex with a bisubstrate inhibitor
Structure deposition date
2021-05-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
88
Peptide accession
Q5VZE5
Residue number A
112
Residue number B
115
Peptide name
N-alpha-acetyltransferase 35, NatC auxiliary subunit

Ligandability

Cysteine 112 of N-alpha-acetyltransferase 35, NatC auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of N-alpha-acetyltransferase 35, NatC auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-alpha-acetyltransferase 35, NatC auxiliary subunit between cysteines 114 and 115. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7mx2
Structure name
cryo-em structure of human ternary natc complex with a bisubstrate inhibitor
Structure deposition date
2021-05-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
70
Peptide accession
Q5VZE5
Residue number A
114
Residue number B
115
Peptide name
N-alpha-acetyltransferase 35, NatC auxiliary subunit

Ligandability

Cysteine 114 of N-alpha-acetyltransferase 35, NatC auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of N-alpha-acetyltransferase 35, NatC auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-alpha-acetyltransferase 35, NatC auxiliary subunit between cysteines 112 and 114. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
7mx2
Structure name
cryo-em structure of human ternary natc complex with a bisubstrate inhibitor
Structure deposition date
2021-05-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
82
Peptide accession
Q5VZE5
Residue number A
112
Residue number B
114
Peptide name
N-alpha-acetyltransferase 35, NatC auxiliary subunit

Ligandability

Cysteine 112 of N-alpha-acetyltransferase 35, NatC auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of N-alpha-acetyltransferase 35, NatC auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-alpha-acetyltransferase 35, NatC auxiliary subunit between cysteines 112 and 157. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
7mx2
Structure name
cryo-em structure of human ternary natc complex with a bisubstrate inhibitor
Structure deposition date
2021-05-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
100
Peptide accession
Q5VZE5
Residue number A
112
Residue number B
157
Peptide name
N-alpha-acetyltransferase 35, NatC auxiliary subunit

Ligandability

Cysteine 112 of N-alpha-acetyltransferase 35, NatC auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 157 of N-alpha-acetyltransferase 35, NatC auxiliary subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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