ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Angiogenin

Intramolecular
Cysteine 63 and cysteine 115
Cysteine 81 and cysteine 130
Cysteine 50 and cysteine 104
A redox-regulated disulphide may form within Angiogenin between cysteines 63 and 115 (39 and 91 respectively in this structure).

Details

Redox score ?
87
PDB code
4qfi
Structure name
the crystal structure of rat angiogenin-heparin complex
Structure deposition date
2014-05-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5WRG2
Residue number A
63
Residue number B
115
Peptide name
Angiogenin

Ligandability

Cysteine 63 of Angiogenin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Angiogenin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Angiogenin between cysteines 81 and 130 (57 and 106 respectively in this structure).

Details

Redox score ?
84
PDB code
4qfi
Structure name
the crystal structure of rat angiogenin-heparin complex
Structure deposition date
2014-05-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5WRG2
Residue number A
81
Residue number B
130
Peptide name
Angiogenin

Ligandability

Cysteine 81 of Angiogenin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Angiogenin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Angiogenin between cysteines 50 and 104 (26 and 80 respectively in this structure).

Details

Redox score ?
84
PDB code
4qfj
Structure name
the crystal structure of rat angiogenin-heparin complex
Structure deposition date
2014-05-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5WRG2
Residue number A
50
Residue number B
104
Peptide name
Angiogenin

Ligandability

Cysteine 50 of Angiogenin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Angiogenin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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