ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA class II histocompatibility antigen DR beta chain

Intramolecular
Cysteine 146 and cysteine 202
Cysteine 44 and cysteine 108
A redox-regulated disulphide may form within HLA class II histocompatibility antigen DR beta chain between cysteines 146 and 202 (117 and 173 respectively in this structure).

Details

Redox score ?
79
PDB code
7n19
Structure name
dr3 in complex with aspergillus nidulans nad-dependent histone deacetylase hst4 peptide
Structure deposition date
2021-05-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5Y7D1
Residue number A
146
Residue number B
202
Peptide name
HLA class II histocompatibility antigen DR beta chain

Ligandability

Cysteine 146 of HLA class II histocompatibility antigen DR beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of HLA class II histocompatibility antigen DR beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class II histocompatibility antigen DR beta chain between cysteines 44 and 108 (15 and 79 respectively in this structure).

Details

Redox score ?
79
PDB code
7n19
Structure name
dr3 in complex with aspergillus nidulans nad-dependent histone deacetylase hst4 peptide
Structure deposition date
2021-05-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5Y7D1
Residue number A
44
Residue number B
108
Peptide name
HLA class II histocompatibility antigen DR beta chain

Ligandability

Cysteine 44 of HLA class II histocompatibility antigen DR beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of HLA class II histocompatibility antigen DR beta chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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