ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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C-type lectin domain family 4, member a4

Intramolecular
Cysteine 107 and cysteine 118
Cysteine 204 and cysteine 221
Cysteine 136 and cysteine 229
A redox-regulated disulphide may form within C-type lectin domain family 4, member a4 between cysteines 107 and 118.

Details

Redox score ?
85
PDB code
3vyj
Structure name
crystal structure of c-type lectin domain of murine dendritic cell inhibitory receptor 2 (apo form)
Structure deposition date
2012-09-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5YIR8
Residue number A
107
Residue number B
118
Peptide name
C-type lectin domain family 4, member a4

Ligandability

Cysteine 107 of C-type lectin domain family 4, member a4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of C-type lectin domain family 4, member a4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-type lectin domain family 4, member a4 between cysteines 204 and 221.

Details

Redox score ?
82
PDB code
3vyj
Structure name
crystal structure of c-type lectin domain of murine dendritic cell inhibitory receptor 2 (apo form)
Structure deposition date
2012-09-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5YIR8
Residue number A
204
Residue number B
221
Peptide name
C-type lectin domain family 4, member a4

Ligandability

Cysteine 204 of C-type lectin domain family 4, member a4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 221 of C-type lectin domain family 4, member a4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within C-type lectin domain family 4, member a4 between cysteines 136 and 229.

Details

Redox score ?
82
PDB code
3vyj
Structure name
crystal structure of c-type lectin domain of murine dendritic cell inhibitory receptor 2 (apo form)
Structure deposition date
2012-09-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q5YIR8
Residue number A
136
Residue number B
229
Peptide name
C-type lectin domain family 4, member a4

Ligandability

Cysteine 136 of C-type lectin domain family 4, member a4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 229 of C-type lectin domain family 4, member a4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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