ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

CD276 antigen

Intramolecular
Cysteine 50 and cysteine 122
Cysteine 165 and cysteine 220
A redox-regulated disulphide may form within CD276 antigen between cysteines 50 and 122.

Details

Redox score ?
85
PDB code
4i0k
Structure name
crystal structure of murine b7-h3 extracellular domain
Structure deposition date
2012-11-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VE98
Residue number A
50
Residue number B
122
Peptide name
CD276 antigen

Ligandability

Cysteine 50 of CD276 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of CD276 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CD276 antigen between cysteines 165 and 220.

Details

Redox score ?
80
PDB code
4i0k
Structure name
crystal structure of murine b7-h3 extracellular domain
Structure deposition date
2012-11-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8VE98
Residue number A
165
Residue number B
220
Peptide name
CD276 antigen

Ligandability

Cysteine 165 of CD276 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of CD276 antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: