ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

protein-tyrosine-phosphatase

Intramolecular
Cysteine 1020 and cysteine 1028
Cysteine 1028 and cysteine 1118
A redox-regulated disulphide may form within protein-tyrosine-phosphatase between cysteines 1020 and 1028.

Details

Redox score ?
60
PDB code
3i36
Structure name
crystal structure of rat protein tyrosine phosphatase eta catalytic domain
Structure deposition date
2009-06-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
82
Peptide accession
Q62884
Residue number A
1020
Residue number B
1028
Peptide name
protein-tyrosine-phosphatase

Ligandability

Cysteine 1020 of protein-tyrosine-phosphatase

Cysteine 1028 of protein-tyrosine-phosphatase

A redox-regulated disulphide may form within protein-tyrosine-phosphatase between cysteines 1028 and 1118. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3i36
Structure name
crystal structure of rat protein tyrosine phosphatase eta catalytic domain
Structure deposition date
2009-06-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
9
% buried
100
Peptide accession
Q62884
Residue number A
1028
Residue number B
1118
Peptide name
protein-tyrosine-phosphatase

Ligandability

Cysteine 1028 of protein-tyrosine-phosphatase

Cysteine 1118 of protein-tyrosine-phosphatase

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