ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Teashirt homolog 3

Intramolecular
Cysteine 277 and cysteine 280
Cysteine 216 and cysteine 219
A redox-regulated disulphide may form within Teashirt homolog 3 between cysteines 277 and 280 (83 and 86 respectively in this structure).

Details

Redox score ?
87
PDB code
2dmi
Structure name
solution structure of the first and the second zf-c2h2 like domains of human teashirt homolog 3
Structure deposition date
2006-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
41
Minimum pKa ?
7
% buried
0
Peptide accession
Q63HK5
Residue number A
277
Residue number B
280
Peptide name
Teashirt homolog 3

Ligandability

Cysteine 277 of Teashirt homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 280 of Teashirt homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Teashirt homolog 3 between cysteines 216 and 219 (22 and 25 respectively in this structure).

Details

Redox score ?
84
PDB code
2dmi
Structure name
solution structure of the first and the second zf-c2h2 like domains of human teashirt homolog 3
Structure deposition date
2006-04-21
Thiol separation (Å)
4
Half-sphere exposure sum ?
44
Minimum pKa ?
8
% buried
0
Peptide accession
Q63HK5
Residue number A
216
Residue number B
219
Peptide name
Teashirt homolog 3

Ligandability

Cysteine 216 of Teashirt homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Teashirt homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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