a tool for identifying drug-targetable redox-active disulphides

Tensin-2

Intramolecular

Cysteine 1241 and cysteine 1242

A redox-regulated disulphide may form within Tensin-2 between cysteines 1241 and 1242 (108 and 109 respectively in this structure).

Details

Redox score ?

68

PDB code

Structure name

solution structure of a nonphosphorylated peptide recognizing domain

Structure deposition date

2010-11-22

Thiol separation (Å)

5

Half-sphere exposure sum ?

52

Minimum pK_a ?

9

% buried

0

Peptide accession

Residue number A

1241

Residue number B

1242

Peptide name

Tensin-2

Ligandability

Cysteine 1241 of Tensin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1242 of Tensin-2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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