ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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KN motif and ankyrin repeat domain-containing protein 2

Intramolecular
Cysteine 780 and cysteine 797
Cysteine 778 and cysteine 780
A redox-regulated disulphide may form within KN motif and ankyrin repeat domain-containing protein 2 between cysteines 780 and 797. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4hbd
Structure name
crystal structure of kank2 ankyrin repeats
Structure deposition date
2012-09-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q63ZY3
Residue number A
780
Residue number B
797
Peptide name
KN motif and ankyrin repeat domain-containing protein 2

Ligandability

Cysteine 780 of KN motif and ankyrin repeat domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 797 of KN motif and ankyrin repeat domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within KN motif and ankyrin repeat domain-containing protein 2 between cysteines 778 and 780. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
6tmd
Structure name
crystal structure of kank2 ankyrin repeats mutant (a670v)
Structure deposition date
2019-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
75
Peptide accession
Q63ZY3
Residue number A
778
Residue number B
780
Peptide name
KN motif and ankyrin repeat domain-containing protein 2

Ligandability

Cysteine 778 of KN motif and ankyrin repeat domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 780 of KN motif and ankyrin repeat domain-containing protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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