a tool for identifying drug-targetable redox-active disulphides

Meteorin-like protein

Intramolecular

Cysteine 201 and cysteine 306

Cysteine 191 and cysteine 284

Cysteine 188 and cysteine 260

Cysteine 191 and cysteine 260

A redox-regulated disulphide may form within Meteorin-like protein between cysteines 201 and 306 (156 and 261 respectively in this structure).

Details

Redox score ?

84

PDB code

Structure name

murine meteorin-like c-terminal ntr domain

Structure deposition date

2022-01-19

Thiol separation (Å)

2

Half-sphere exposure sum ?

40

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

201

Residue number B

306

Peptide name

Meteorin-like protein

Ligandability

Cysteine 201 of Meteorin-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 306 of Meteorin-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meteorin-like protein between cysteines 191 and 284 (146 and 239 respectively in this structure).

Details

Redox score ?

83

PDB code

Structure name

murine meteorin-like c-terminal ntr domain

Structure deposition date

2022-01-19

Thiol separation (Å)

2

Half-sphere exposure sum ?

61

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

191

Residue number B

284

Peptide name

Meteorin-like protein

Ligandability

Cysteine 191 of Meteorin-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Meteorin-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meteorin-like protein between cysteines 188 and 260 (143 and 215 respectively in this structure).

Details

Redox score ?

80

PDB code

Structure name

murine meteorin-like c-terminal ntr domain

Structure deposition date

2022-01-19

Thiol separation (Å)

4

Half-sphere exposure sum ?

nan

Minimum pK_a ?

9

% buried

nan

Peptide accession

Residue number A

188

Residue number B

260

Peptide name

Meteorin-like protein

Ligandability

Cysteine 188 of Meteorin-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Meteorin-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meteorin-like protein between cysteines 191 and 260 (146 and 215 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

43

PDB code

Structure name

murine meteorin-like c-terminal ntr domain

Structure deposition date

2022-01-19

Thiol separation (Å)

10

Half-sphere exposure sum ?

47

Minimum pK_a ?

9

% buried

nan

Peptide accession

Residue number A

191

Residue number B

260

Peptide name

Meteorin-like protein

Ligandability

Cysteine 191 of Meteorin-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Meteorin-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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