ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Kappa light chain C_region

Intramolecular
Cysteine 23 and cysteine 93
Cysteine 139 and cysteine 199
A redox-regulated disulphide may form within Kappa light chain C_region between cysteines 23 and 93 (23 and 88 respectively in this structure).

Details

Redox score ?
80
PDB code
2gk0
Structure name
structure of catalytic elimination antibody 13g5 from a twinned crystal in space group c2
Structure deposition date
2006-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
92
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q65ZC0
Residue number A
23
Residue number B
93
Peptide name
Kappa light chain C_region

Ligandability

Cysteine 23 of Kappa light chain C_region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Kappa light chain C_region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kappa light chain C_region between cysteines 139 and 199 (134 and 194 respectively in this structure).

Details

Redox score ?
77
PDB code
2gk0
Structure name
structure of catalytic elimination antibody 13g5 from a twinned crystal in space group c2
Structure deposition date
2006-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q65ZC0
Residue number A
139
Residue number B
199
Peptide name
Kappa light chain C_region

Ligandability

Cysteine 139 of Kappa light chain C_region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of Kappa light chain C_region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: