ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Single-chain Fv

Intramolecular
Cysteine 22 and cysteine 96
Cysteine 155 and cysteine 220
A redox-regulated disulphide may form within Single-chain Fv between cysteines 22 and 96.

Details

Redox score ?
80
PDB code
2ghw
Structure name
crystal structure of sars spike protein receptor binding domain in complex with a neutralizing antibody, 80r
Structure deposition date
2006-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q65ZC9
Residue number A
22
Residue number B
96
Peptide name
Single-chain Fv

Ligandability

Cysteine 22 of Single-chain Fv

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Single-chain Fv

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Single-chain Fv between cysteines 155 and 220.

Details

Redox score ?
78
PDB code
2ghw
Structure name
crystal structure of sars spike protein receptor binding domain in complex with a neutralizing antibody, 80r
Structure deposition date
2006-03-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q65ZC9
Residue number A
155
Residue number B
220
Peptide name
Single-chain Fv

Ligandability

Cysteine 155 of Single-chain Fv

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Single-chain Fv

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: