ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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AP-2 complex subunit alpha

Intramolecular
Cysteine 492 and cysteine 533
Cysteine 134 and cysteine 171
A redox-regulated disulphide may form within AP-2 complex subunit alpha between cysteines 492 and 533. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2xa7
Structure name
ap2 clathrin adaptor core in active complex with cargo peptides
Structure deposition date
2010-03-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
69
Peptide accession
Q66HM2
Residue number A
492
Residue number B
533
Peptide name
AP-2 complex subunit alpha

Ligandability

Cysteine 492 of AP-2 complex subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 533 of AP-2 complex subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within AP-2 complex subunit alpha between cysteines 134 and 171. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
6uri
Structure name
hiv-1 nef in complex with the cd4 cytoplasmic domain and the ap2 clathrin adaptor complex
Structure deposition date
2019-10-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
100
Minimum pKa ?
12
% buried
100
Peptide accession
Q66HM2
Residue number A
134
Residue number B
171
Peptide name
AP-2 complex subunit alpha

Ligandability

Cysteine 134 of AP-2 complex subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 171 of AP-2 complex subunit alpha

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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