ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

DDB1- and CUL4-associated factor 15

Intramolecular
Cysteine 193 and cysteine 211
Cysteine 196 and cysteine 211
Cysteine 193 and cysteine 196
A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 15 between cysteines 193 and 211.

Details

Redox score ?
89
PDB code
6pai
Structure name
structure of the human ddb1-dda1-dcaf15 e3 ubiquitin ligase bound to rbm39 and sulfonamide e7820
Structure deposition date
2019-06-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
2
% buried
42
Peptide accession
Q66K64
Residue number A
193
Residue number B
211
Peptide name
DDB1- and CUL4-associated factor 15

Ligandability

Cysteine 193 of DDB1- and CUL4-associated factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of DDB1- and CUL4-associated factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 15 between cysteines 196 and 211.

Details

Redox score ?
79
PDB code
6q0v
Structure name
structure of ddb1-dda1-dcaf15 complex bound to tasisulam and rbm39
Structure deposition date
2019-08-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
8
% buried
32
Peptide accession
Q66K64
Residue number A
196
Residue number B
211
Peptide name
DDB1- and CUL4-associated factor 15

Ligandability

Cysteine 196 of DDB1- and CUL4-associated factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of DDB1- and CUL4-associated factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DDB1- and CUL4-associated factor 15 between cysteines 193 and 196.

Details

Redox score ?
79
PDB code
6pai
Structure name
structure of the human ddb1-dda1-dcaf15 e3 ubiquitin ligase bound to rbm39 and sulfonamide e7820
Structure deposition date
2019-06-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
9
% buried
44
Peptide accession
Q66K64
Residue number A
193
Residue number B
196
Peptide name
DDB1- and CUL4-associated factor 15

Ligandability

Cysteine 193 of DDB1- and CUL4-associated factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 196 of DDB1- and CUL4-associated factor 15

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: