ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Small nuclear ribonucleoprotein-associated protein

Intramolecular
Cysteine 19 and cysteine 45
Cysteine 43 and cysteine 45
A redox-regulated disulphide may form within Small nuclear ribonucleoprotein-associated protein between cysteines 19 and 45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7b0y
Structure name
structure of a transcribing rna polymerase ii-u1 snrnp complex
Structure deposition date
2020-11-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
92
Peptide accession
Q66K91
Residue number A
19
Residue number B
45
Peptide name
Small nuclear ribonucleoprotein-associated protein

Ligandability

Cysteine 19 of Small nuclear ribonucleoprotein-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 45 of Small nuclear ribonucleoprotein-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Small nuclear ribonucleoprotein-associated protein between cysteines 43 and 45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7b0y
Structure name
structure of a transcribing rna polymerase ii-u1 snrnp complex
Structure deposition date
2020-11-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
70
Peptide accession
Q66K91
Residue number A
43
Residue number B
45
Peptide name
Small nuclear ribonucleoprotein-associated protein

Ligandability

Cysteine 43 of Small nuclear ribonucleoprotein-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 45 of Small nuclear ribonucleoprotein-associated protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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