ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HAUS augmin-like complex subunit 3

Intermolecular
Cysteine 511 and cysteine 241 of HAUS augmin-like complex subunit 4
Cysteine 156 of HAUS augmin-like complex subunit 1 and cysteine 511 L
Intramolecular
Cysteine 3 and cysteine 44
A redox-regulated disulphide may form between cysteine 511 of HAUS augmin-like complex subunit 3 and cysteine 241 of HAUS augmin-like complex subunit 4 (511 and 196 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7sqk
Structure name
cryo-em structure of the human augmin complex
Structure deposition date
2021-11-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
70
Peptide A name
HAUS augmin-like complex subunit 3
Peptide B name
HAUS augmin-like complex subunit 4
Peptide A accession
Q68CZ6
Peptide B accession
Q9H6D7
Peptide A residue number
511
Peptide B residue number
241

Ligandability

Cysteine 511 of HAUS augmin-like complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of HAUS augmin-like complex subunit 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 156 of HAUS augmin-like complex subunit 1 and cysteine 511 of HAUS augmin-like complex subunit 3. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7sqk
Structure name
cryo-em structure of the human augmin complex
Structure deposition date
2021-11-05
Thiol separation (Å)
9
Half-sphere exposure sum ?
59
Minimum pKa ?
9
% buried
40
Peptide A name
HAUS augmin-like complex subunit 1
Peptide B name
HAUS augmin-like complex subunit 3
Peptide A accession
Q96CS2
Peptide B accession
Q68CZ6
Peptide A residue number
156
Peptide B residue number
511

Ligandability

Cysteine 156 of HAUS augmin-like complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 511 of HAUS augmin-like complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HAUS augmin-like complex subunit 3 between cysteines 3 and 44. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7sqk
Structure name
cryo-em structure of the human augmin complex
Structure deposition date
2021-11-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
27
Peptide accession
Q68CZ6
Residue number A
3
Residue number B
44
Peptide name
HAUS augmin-like complex subunit 3

Ligandability

Cysteine 3 of HAUS augmin-like complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 44 of HAUS augmin-like complex subunit 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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