ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Natural cytotoxicity triggering receptor 3 ligand 1

Intramolecular
Cysteine 48 and cysteine 122
Cysteine 163 and cysteine 228
Cysteine 163 and cysteine 212
A redox-regulated disulphide may form within Natural cytotoxicity triggering receptor 3 ligand 1 between cysteines 48 and 122.

Details

Redox score ?
82
PDB code
3pv7
Structure name
crystal structure of nkp30 ligand b7-h6
Structure deposition date
2010-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q68D85
Residue number A
48
Residue number B
122
Peptide name
Natural cytotoxicity triggering receptor 3 ligand 1

Ligandability

Cysteine 48 of Natural cytotoxicity triggering receptor 3 ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 122 of Natural cytotoxicity triggering receptor 3 ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Natural cytotoxicity triggering receptor 3 ligand 1 between cysteines 163 and 228.

Details

Redox score ?
80
PDB code
3pv7
Structure name
crystal structure of nkp30 ligand b7-h6
Structure deposition date
2010-12-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q68D85
Residue number A
163
Residue number B
228
Peptide name
Natural cytotoxicity triggering receptor 3 ligand 1

Ligandability

Cysteine 163 of Natural cytotoxicity triggering receptor 3 ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 228 of Natural cytotoxicity triggering receptor 3 ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Natural cytotoxicity triggering receptor 3 ligand 1 between cysteines 163 and 212. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3pv7
Structure name
crystal structure of nkp30 ligand b7-h6
Structure deposition date
2010-12-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
9
% buried
nan
Peptide accession
Q68D85
Residue number A
163
Residue number B
212
Peptide name
Natural cytotoxicity triggering receptor 3 ligand 1

Ligandability

Cysteine 163 of Natural cytotoxicity triggering receptor 3 ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 212 of Natural cytotoxicity triggering receptor 3 ligand 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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