ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Male-specific lethal 1 homolog

Intermolecular
Cysteine 221 and cysteine 107 of E3 ubiquitin-protein ligase MSL2 L
A redox-regulated disulphide may form between cysteine 221 of Male-specific lethal 1 homolog and cysteine 107 of E3 ubiquitin-protein ligase MSL2. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
4b7y
Structure name
crystal structure of the msl1-msl2 complex
Structure deposition date
2012-08-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
46
Peptide A name
Male-specific lethal 1 homolog
Peptide B name
E3 ubiquitin-protein ligase MSL2
Peptide A accession
Q68DK7
Peptide B accession
Q9HCI7
Peptide A residue number
221
Peptide B residue number
107

Ligandability

Cysteine 221 of Male-specific lethal 1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 107 of E3 ubiquitin-protein ligase MSL2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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