a tool for identifying drug-targetable redox-active disulphides

E3 ubiquitin-protein ligase RNF43

Intramolecular

Cysteine 91 and cysteine 119

A redox-regulated disulphide may form within E3 ubiquitin-protein ligase RNF43 between cysteines 91 and 119.

Details

Redox score ?

84

PDB code

Structure name

crystal structure of human lgr5-rspo1-rnf43

Structure deposition date

2013-05-09

Thiol separation (Å)

2

Half-sphere exposure sum ?

45

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

91

Residue number B

119

Peptide name

E3 ubiquitin-protein ligase RNF43

Ligandability

Cysteine 91 of E3 ubiquitin-protein ligase RNF43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 119 of E3 ubiquitin-protein ligase RNF43

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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