ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TRIM5/cyclophilin A V4 fusion protein

Intramolecular
Cysteine 96 and cysteine 118
Cysteine 96 and cysteine 115
Cysteine 115 and cysteine 118
Cysteine 161 and cysteine 186
A redox-regulated disulphide may form within TRIM5/cyclophilin A V4 fusion protein between cysteines 96 and 118.

Details

Redox score ?
89
PDB code
5va4
Structure name
trim-cyclophilin a b-box 2 and coiled-coil chimera
Structure deposition date
2017-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
5
% buried
6
Peptide accession
Q68KK2
Residue number A
96
Residue number B
118
Peptide name
TRIM5/cyclophilin A V4 fusion protein

Ligandability

Cysteine 96 of TRIM5/cyclophilin A V4 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of TRIM5/cyclophilin A V4 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TRIM5/cyclophilin A V4 fusion protein between cysteines 96 and 115.

Details

Redox score ?
88
PDB code
5va4
Structure name
trim-cyclophilin a b-box 2 and coiled-coil chimera
Structure deposition date
2017-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
5
% buried
1
Peptide accession
Q68KK2
Residue number A
96
Residue number B
115
Peptide name
TRIM5/cyclophilin A V4 fusion protein

Ligandability

Cysteine 96 of TRIM5/cyclophilin A V4 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of TRIM5/cyclophilin A V4 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TRIM5/cyclophilin A V4 fusion protein between cysteines 115 and 118.

Details

Redox score ?
79
PDB code
5va4
Structure name
trim-cyclophilin a b-box 2 and coiled-coil chimera
Structure deposition date
2017-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
6
Peptide accession
Q68KK2
Residue number A
115
Residue number B
118
Peptide name
TRIM5/cyclophilin A V4 fusion protein

Ligandability

Cysteine 115 of TRIM5/cyclophilin A V4 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of TRIM5/cyclophilin A V4 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TRIM5/cyclophilin A V4 fusion protein between cysteines 161 and 186.

Details

Redox score ?
nan
PDB code
5va4
Structure name
trim-cyclophilin a b-box 2 and coiled-coil chimera
Structure deposition date
2017-03-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
0
Peptide accession
Q68KK2
Residue number A
161
Residue number B
186
Peptide name
TRIM5/cyclophilin A V4 fusion protein

Ligandability

Cysteine 161 of TRIM5/cyclophilin A V4 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of TRIM5/cyclophilin A V4 fusion protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 in protein A could not be asigned to a Uniprot residue.
Cysteine 186 in protein B could not be asigned to a Uniprot residue.
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