ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein virilizer homolog

Intramolecular
Cysteine 938 and cysteine 942
Cysteine 1185 and cysteine 1238
Cysteine 1559 and cysteine 1560
Cysteine 1343 and cysteine 1347
Cysteine 938 and cysteine 1008
Cysteine 1329 and cysteine 1343
Cysteine 1181 and cysteine 1185
Cysteine 1181 and cysteine 1238
Cysteine 942 and cysteine 1008
Cysteine 1329 and cysteine 1347
More...
Cysteine 1291 and cysteine 1327
Cysteine 852 and cysteine 879
Cysteine 1327 and cysteine 1329
Cysteine 1291 and cysteine 1329
A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 938 and 942.

Details

Redox score ?
68
PDB code
7vf2
Structure name
human m6a-mettl associated complex (wtap, virma, zc3h13, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
98
Peptide accession
Q69YN4
Residue number A
938
Residue number B
942
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 938 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 942 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1185 and 1238.

Details

Redox score ?
68
PDB code
7vf2
Structure name
human m6a-mettl associated complex (wtap, virma, zc3h13, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
3
Half-sphere exposure sum ?
99
Minimum pKa ?
9
% buried
100
Peptide accession
Q69YN4
Residue number A
1185
Residue number B
1238
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1185 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1238 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1559 and 1560.

Details

Redox score ?
63
PDB code
7vf2
Structure name
human m6a-mettl associated complex (wtap, virma, zc3h13, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
24
Peptide accession
Q69YN4
Residue number A
1559
Residue number B
1560
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1559 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1560 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1343 and 1347. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7vf5
Structure name
human m6a-mettl associated complex (wtap, virma, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
90
Peptide accession
Q69YN4
Residue number A
1343
Residue number B
1347
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1343 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1347 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 938 and 1008. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7vf2
Structure name
human m6a-mettl associated complex (wtap, virma, zc3h13, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
80
Minimum pKa ?
14
% buried
98
Peptide accession
Q69YN4
Residue number A
938
Residue number B
1008
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 938 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1008 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1329 and 1343. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
7vf2
Structure name
human m6a-mettl associated complex (wtap, virma, zc3h13, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
7
% buried
94
Peptide accession
Q69YN4
Residue number A
1329
Residue number B
1343
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1329 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1343 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1181 and 1185. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7vf5
Structure name
human m6a-mettl associated complex (wtap, virma, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
6
Half-sphere exposure sum ?
97
Minimum pKa ?
13
% buried
100
Peptide accession
Q69YN4
Residue number A
1181
Residue number B
1185
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1181 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1185 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1181 and 1238. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7vf5
Structure name
human m6a-mettl associated complex (wtap, virma, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
97
Minimum pKa ?
9
% buried
100
Peptide accession
Q69YN4
Residue number A
1181
Residue number B
1238
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1181 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1238 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 942 and 1008. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7vf5
Structure name
human m6a-mettl associated complex (wtap, virma, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
9
% buried
100
Peptide accession
Q69YN4
Residue number A
942
Residue number B
1008
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 942 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1008 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1329 and 1347. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7vf2
Structure name
human m6a-mettl associated complex (wtap, virma, zc3h13, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
90
Minimum pKa ?
12
% buried
100
Peptide accession
Q69YN4
Residue number A
1329
Residue number B
1347
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1329 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1347 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1291 and 1327. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7vf5
Structure name
human m6a-mettl associated complex (wtap, virma, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
100
Peptide accession
Q69YN4
Residue number A
1291
Residue number B
1327
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1291 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1327 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 852 and 879. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7vf2
Structure name
human m6a-mettl associated complex (wtap, virma, zc3h13, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
86
Peptide accession
Q69YN4
Residue number A
852
Residue number B
879
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 852 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 879 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1327 and 1329. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
7vf5
Structure name
human m6a-mettl associated complex (wtap, virma, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q69YN4
Residue number A
1327
Residue number B
1329
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1327 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1329 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein virilizer homolog between cysteines 1291 and 1329. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
24
PDB code
7vf5
Structure name
human m6a-mettl associated complex (wtap, virma, and hakai)
Structure deposition date
2021-09-10
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
100
Peptide accession
Q69YN4
Residue number A
1291
Residue number B
1329
Peptide name
Protein virilizer homolog

Ligandability

Cysteine 1291 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1329 of Protein virilizer homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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