ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lysine-specific demethylase 4D

Intramolecular
Cysteine 238 and cysteine 310
Cysteine 310 and cysteine 312
Cysteine 238 and cysteine 312
A redox-regulated disulphide may form within Lysine-specific demethylase 4D between cysteines 238 and 310.

Details

Redox score ?
97
PDB code
4hoo
Structure name
crystal structure of human jmjd2d/kdm4d apoenzyme
Structure deposition date
2012-10-22
Thiol separation (Å)
3
Half-sphere exposure sum ?
48
Minimum pKa ?
4
% buried
4
Peptide accession
Q6B0I6
Residue number A
238
Residue number B
310
Peptide name
Lysine-specific demethylase 4D

Ligandability

Cysteine 238 of Lysine-specific demethylase 4D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 310 of Lysine-specific demethylase 4D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysine-specific demethylase 4D between cysteines 310 and 312.

Details

Redox score ?
93
PDB code
4hoo
Structure name
crystal structure of human jmjd2d/kdm4d apoenzyme
Structure deposition date
2012-10-22
Thiol separation (Å)
3
Half-sphere exposure sum ?
44
Minimum pKa ?
4
% buried
0
Peptide accession
Q6B0I6
Residue number A
310
Residue number B
312
Peptide name
Lysine-specific demethylase 4D

Ligandability

Cysteine 310 of Lysine-specific demethylase 4D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Lysine-specific demethylase 4D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lysine-specific demethylase 4D between cysteines 238 and 312.

Details

Redox score ?
78
PDB code
5phc
Structure name
pandda analysis group deposition -- crystal structure of jmjd2d in complex with n09649a
Structure deposition date
2017-02-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
20
Peptide accession
Q6B0I6
Residue number A
238
Residue number B
312
Peptide name
Lysine-specific demethylase 4D

Ligandability

Cysteine 238 of Lysine-specific demethylase 4D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 312 of Lysine-specific demethylase 4D

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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