ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Rab15 effector protein

Intramolecular
Cysteine 152 and cysteine 159
Cysteine 21 and cysteine 218
A redox-regulated disulphide may form within Rab15 effector protein between cysteines 152 and 159.

Details

Redox score ?
69
PDB code
8a4b
Structure name
structure of human rep15:rab3b_q81l complex
Structure deposition date
2022-06-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
98
Peptide accession
Q6BDI9
Residue number A
152
Residue number B
159
Peptide name
Rab15 effector protein

Ligandability

Cysteine 152 of Rab15 effector protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of Rab15 effector protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Rab15 effector protein between cysteines 21 and 218. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
8a4a
Structure name
structure of human rep15 in complex with bovine rab3c
Structure deposition date
2022-06-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
62
Peptide accession
Q6BDI9
Residue number A
21
Residue number B
218
Peptide name
Rab15 effector protein

Ligandability

Cysteine 21 of Rab15 effector protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of Rab15 effector protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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