ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IQ motif and SEC7 domain-containing protein 1

Intramolecular
Cysteine 755 and cysteine 757
Cysteine 636 and cysteine 638
A redox-regulated disulphide may form within IQ motif and SEC7 domain-containing protein 1 between cysteines 755 and 757 (741 and 743 respectively in this structure).

Details

Redox score ?
67
PDB code
3qwm
Structure name
crystal structure of gep100, the plextrin homology domain of iq motif and sec7 domain-containing protein 1 isoform a
Structure deposition date
2011-02-28
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
55
Peptide accession
Q6DN90
Residue number A
755
Residue number B
757
Peptide name
IQ motif and SEC7 domain-containing protein 1

Ligandability

Cysteine 755 of IQ motif and SEC7 domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 757 of IQ motif and SEC7 domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IQ motif and SEC7 domain-containing protein 1 between cysteines 636 and 638 (514 and 516 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6fne
Structure name
structure of human brag2 (sec7-ph domains) with the inhibitor bragsin bound to the ph domain
Structure deposition date
2018-02-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
9
% buried
28
Peptide accession
Q6DN90
Residue number A
636
Residue number B
638
Peptide name
IQ motif and SEC7 domain-containing protein 1

Ligandability

Cysteine 636 of IQ motif and SEC7 domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 638 of IQ motif and SEC7 domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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