ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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General transcription factor II-I repeat domain-containing protein 2B

Intramolecular
Cysteine 116 and cysteine 118
A redox-regulated disulphide may form within General transcription factor II-I repeat domain-containing protein 2B between cysteines 116 and 118 (17 and 19 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
2e3l
Structure name
solution structure of rsgi ruh-068, a gtf2i domain in human cdna
Structure deposition date
2006-11-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
42
Peptide accession
Q6EKJ0
Residue number A
116
Residue number B
118
Peptide name
General transcription factor II-I repeat domain-containing protein 2B

Ligandability

Cysteine 116 of General transcription factor II-I repeat domain-containing protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 118 of General transcription factor II-I repeat domain-containing protein 2B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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