ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Annexin

Intramolecular
Cysteine 242 and cysteine 246
Cysteine 114 and cysteine 242
Cysteine 114 and cysteine 246
A redox-regulated disulphide may form within Annexin between cysteines 242 and 246.

Details

Redox score ?
77
PDB code
6b3i
Structure name
annexin a13a
Structure deposition date
2017-09-21
Thiol separation (Å)
3
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
94
Peptide accession
Q6FHB6
Residue number A
242
Residue number B
246
Peptide name
Annexin

Ligandability

Cysteine 242 of Annexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 246 of Annexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Annexin between cysteines 114 and 242. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6b3i
Structure name
annexin a13a
Structure deposition date
2017-09-21
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
nan
Peptide accession
Q6FHB6
Residue number A
114
Residue number B
242
Peptide name
Annexin

Ligandability

Cysteine 114 of Annexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 242 of Annexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Annexin between cysteines 114 and 246. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6b3i
Structure name
annexin a13a
Structure deposition date
2017-09-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
nan
Peptide accession
Q6FHB6
Residue number A
114
Residue number B
246
Peptide name
Annexin

Ligandability

Cysteine 114 of Annexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 246 of Annexin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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