ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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[tau protein] kinase

Intramolecular
Cysteine 218 and cysteine 245
Cysteine 245 and cysteine 317
Cysteine 178 and cysteine 218
A redox-regulated disulphide may form within [tau protein] kinase between cysteines 218 and 245. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4nm5
Structure name
crystal structure of gsk-3/axin complex bound to phosphorylated wnt receptor lrp6 c-motif
Structure deposition date
2013-11-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
13
% buried
100
Peptide accession
Q6FI27
Residue number A
218
Residue number B
245
Peptide name
[tau protein] kinase

Ligandability

Cysteine 218 of [tau protein] kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 245 of [tau protein] kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within [tau protein] kinase between cysteines 245 and 317. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4nm5
Structure name
crystal structure of gsk-3/axin complex bound to phosphorylated wnt receptor lrp6 c-motif
Structure deposition date
2013-11-14
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
13
% buried
100
Peptide accession
Q6FI27
Residue number A
245
Residue number B
317
Peptide name
[tau protein] kinase

Ligandability

Cysteine 245 of [tau protein] kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 317 of [tau protein] kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within [tau protein] kinase between cysteines 178 and 218. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4nm5
Structure name
crystal structure of gsk-3/axin complex bound to phosphorylated wnt receptor lrp6 c-motif
Structure deposition date
2013-11-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
13
% buried
100
Peptide accession
Q6FI27
Residue number A
178
Residue number B
218
Peptide name
[tau protein] kinase

Ligandability

Cysteine 178 of [tau protein] kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 218 of [tau protein] kinase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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