ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig-like domain-containing protein

Intramolecular
Cysteine 45 and cysteine 110
Cysteine 156 and cysteine 216
A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 45 and 110 (23 and 88 respectively in this structure).

Details

Redox score ?
80
PDB code
2d7t
Structure name
crystal structure of human anti polyhydroxybutyrate antibody fv
Structure deposition date
2005-11-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6GMX0
Residue number A
45
Residue number B
110
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 45 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 156 and 216 (134 and 194 respectively in this structure).

Details

Redox score ?
78
PDB code
6ucf
Structure name
n123-vrc34_pi4 hiv neutralizing antibody in complex with hiv fusion peptide residue 512-519
Structure deposition date
2019-09-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6GMX0
Residue number A
156
Residue number B
216
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 156 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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