ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IGL@ protein

Intramolecular
Cysteine 41 and cysteine 109
Cysteine 158 and cysteine 217
A redox-regulated disulphide may form within IGL@ protein between cysteines 41 and 109 (23 and 88 respectively in this structure).

Details

Redox score ?
80
PDB code
6apd
Structure name
crystal structure of rsv f bound by am22 and the infant antibody adi- 19425
Structure deposition date
2017-08-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6GMX4
Residue number A
41
Residue number B
109
Peptide name
IGL@ protein

Ligandability

Cysteine 41 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGL@ protein between cysteines 158 and 217 (135 and 194 respectively in this structure).

Details

Redox score ?
79
PDB code
6apd
Structure name
crystal structure of rsv f bound by am22 and the infant antibody adi- 19425
Structure deposition date
2017-08-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6GMX4
Residue number A
158
Residue number B
217
Peptide name
IGL@ protein

Ligandability

Cysteine 158 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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