IGH@ protein

Intermolecular

Cysteine 107 of Immunoglobulin kappa constant and cysteine 238

Cysteine 238 and cysteine 235 of IGL@ protein

Cysteine 238 and cysteine 239 of Ig-like domain-containing protein

Intramolecular

A redox-regulated disulphide may form between cysteine 107 of Immunoglobulin kappa constant and cysteine 238 of IGH@ protein (214 and 223 respectively in this structure).

Details

Redox score ?

PDB code

6bah

Structure name

trastuzumab fab v3 with 5-diphenyl meditope variant

Structure deposition date

2017-10-12

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Immunoglobulin kappa constant

Peptide B name

IGH@ protein

Peptide A accession

P01834

Peptide B accession

Q6GMX6

Peptide A residue number

107

Peptide B residue number

238

Ligandability

Cysteine 107 of Immunoglobulin kappa constant

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 238 of IGH@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 238 of IGH@ protein and cysteine 235 of IGL@ protein (224 and 215 respectively in this structure).

Details

Redox score ?

PDB code

5utz

Structure name

human il-2/fab complex

Structure deposition date

2017-02-15

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

nan

% buried

nan

Peptide A name

IGH@ protein

Peptide B name

IGL@ protein

Peptide A accession

Q6GMX6

Peptide B accession

Q6IPQ0

Peptide A residue number

238

Peptide B residue number

235

Ligandability

Cysteine 238 of IGH@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 235 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 238 of IGH@ protein and cysteine 239 of Ig-like domain-containing protein (216 and 214 respectively in this structure).