ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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XIAP-associated factor 1

Intramolecular
Cysteine 267 and cysteine 270
Cysteine 267 and cysteine 286
Cysteine 270 and cysteine 286
A redox-regulated disulphide may form within XIAP-associated factor 1 between cysteines 267 and 270 (21 and 24 respectively in this structure).

Details

Redox score ?
90
PDB code
2lxw
Structure name
the solution structure of xiap(ring)-binding domain of human xaf1
Structure deposition date
2012-09-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
32
Minimum pKa ?
8
% buried
0
Peptide accession
Q6GPH4
Residue number A
267
Residue number B
270
Peptide name
XIAP-associated factor 1

Ligandability

Cysteine 267 of XIAP-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 270 of XIAP-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within XIAP-associated factor 1 between cysteines 267 and 286 (21 and 40 respectively in this structure).

Details

Redox score ?
83
PDB code
2lxw
Structure name
the solution structure of xiap(ring)-binding domain of human xaf1
Structure deposition date
2012-09-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
37
Minimum pKa ?
8
% buried
nan
Peptide accession
Q6GPH4
Residue number A
267
Residue number B
286
Peptide name
XIAP-associated factor 1

Ligandability

Cysteine 267 of XIAP-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of XIAP-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within XIAP-associated factor 1 between cysteines 270 and 286 (24 and 40 respectively in this structure).

Details

Redox score ?
81
PDB code
2lxw
Structure name
the solution structure of xiap(ring)-binding domain of human xaf1
Structure deposition date
2012-09-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
37
Minimum pKa ?
9
% buried
nan
Peptide accession
Q6GPH4
Residue number A
270
Residue number B
286
Peptide name
XIAP-associated factor 1

Ligandability

Cysteine 270 of XIAP-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 286 of XIAP-associated factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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