ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

RAR-related orphan receptor C

Intramolecular
Cysteine 320 and cysteine 393
A redox-regulated disulphide may form within RAR-related orphan receptor C between cysteines 320 and 393. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6vsw
Structure name
optimization and biological evaluation of thiazole-bis-amide inverse agonists of rorgt
Structure deposition date
2020-02-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
10
% buried
70
Peptide accession
Q6I9R9
Residue number A
320
Residue number B
393
Peptide name
RAR-related orphan receptor C

Ligandability

Cysteine 320 of RAR-related orphan receptor C

Cysteine 393 of RAR-related orphan receptor C

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