ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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THO complex subunit 7 homolog

Intermolecular
Cysteine 59 of THO complex subunit 5 homolog and cysteine 60 L
A redox-regulated disulphide may form between cysteine 59 of THO complex subunit 5 homolog and cysteine 60 of THO complex subunit 7 homolog. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7apk
Structure name
structure of the human tho - uap56 complex
Structure deposition date
2020-10-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
11
% buried
64
Peptide A name
THO complex subunit 5 homolog
Peptide B name
THO complex subunit 7 homolog
Peptide A accession
Q13769
Peptide B accession
Q6I9Y2
Peptide A residue number
59
Peptide B residue number
60

Ligandability

Cysteine 59 of THO complex subunit 5 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of THO complex subunit 7 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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