Elongator complex protein 2
Intramolecular
Cysteine 185 and cysteine 204
Cysteine 166 and cysteine 180
Cysteine 784 and cysteine 815
Cysteine 572 and cysteine 675
Cysteine 445 and cysteine 572
Cysteine 13 and cysteine 14
Cysteine 166 and cysteine 227
Cysteine 63 and cysteine 111
8avg B 185 B 204
A redox-regulated disulphide may form within Elongator complex protein 2 between cysteines 185 and 204.
Details
Redox score ?
73
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
11
Peptide accession
Q91WG4
Residue number A
185
Residue number B
204
Peptide name
Elongator complex protein 2
Ligandability
Cysteine 185 of Elongator complex protein 2
Cysteine 204 of Elongator complex protein 2
8avg B 166 B 180
A redox-regulated disulphide may form within Elongator complex protein 2 between cysteines 166 and 180. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
Q91WG4
Residue number A
166
Residue number B
180
Peptide name
Elongator complex protein 2
Ligandability
Cysteine 166 of Elongator complex protein 2
Cysteine 180 of Elongator complex protein 2
8avg B 784 B 815
A redox-regulated disulphide may form within Elongator complex protein 2 between cysteines 784 and 815. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
100
Peptide accession
Q91WG4
Residue number A
784
Residue number B
815
Peptide name
Elongator complex protein 2
Ligandability
Cysteine 784 of Elongator complex protein 2
Cysteine 815 of Elongator complex protein 2
8avg B 572 B 675
A redox-regulated disulphide may form within Elongator complex protein 2 between cysteines 572 and 675. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
100
Peptide accession
Q91WG4
Residue number A
572
Residue number B
675
Peptide name
Elongator complex protein 2
Ligandability
Cysteine 572 of Elongator complex protein 2
Cysteine 675 of Elongator complex protein 2
8avg B 445 B 572
A redox-regulated disulphide may form within Elongator complex protein 2 between cysteines 445 and 572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q91WG4
Residue number A
445
Residue number B
572
Peptide name
Elongator complex protein 2
Ligandability
Cysteine 445 of Elongator complex protein 2
Cysteine 572 of Elongator complex protein 2
8avg B 13 B 14
A redox-regulated disulphide may form within Elongator complex protein 2 between cysteines 13 and 14. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
85
Minimum pKa ?
11
% buried
100
Peptide accession
Q91WG4
Residue number A
13
Residue number B
14
Peptide name
Elongator complex protein 2
Ligandability
Cysteine 13 of Elongator complex protein 2
Cysteine 14 of Elongator complex protein 2
8avg B 166 B 227
A redox-regulated disulphide may form within Elongator complex protein 2 between cysteines 166 and 227. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
100
Peptide accession
Q91WG4
Residue number A
166
Residue number B
227
Peptide name
Elongator complex protein 2
Ligandability
Cysteine 166 of Elongator complex protein 2
Cysteine 227 of Elongator complex protein 2
8avg B 63 B 111
A redox-regulated disulphide may form within Elongator complex protein 2 between cysteines 63 and 111. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
8avg
Structure name
cryo-em structure of mouse elp123 with bound sam
Structure deposition date
2022-08-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
100
Peptide accession
Q91WG4
Residue number A
63
Residue number B
111
Peptide name
Elongator complex protein 2
Ligandability
Cysteine 63 of Elongator complex protein 2
Cysteine 111 of Elongator complex protein 2
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