ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA-DMA protein

Intramolecular
Cysteine 50 and cysteine 105
Cysteine 147 and cysteine 202
A redox-regulated disulphide may form within HLA-DMA protein between cysteines 50 and 105 (24 and 79 respectively in this structure).

Details

Redox score ?
80
PDB code
4i0p
Structure name
hla-do in complex with hla-dm
Structure deposition date
2012-11-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ICR9
Residue number A
50
Residue number B
105
Peptide name
HLA-DMA protein

Ligandability

Cysteine 50 of HLA-DMA protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of HLA-DMA protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA-DMA protein between cysteines 147 and 202 (121 and 176 respectively in this structure).

Details

Redox score ?
79
PDB code
4i0p
Structure name
hla-do in complex with hla-dm
Structure deposition date
2012-11-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6ICR9
Residue number A
147
Residue number B
202
Peptide name
HLA-DMA protein

Ligandability

Cysteine 147 of HLA-DMA protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of HLA-DMA protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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