ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IGL@ protein

Intermolecular
Cysteine 245 of IgG H chain and cysteine 235
Cysteine 238 of IGH@ protein and cysteine 235
Intramolecular
Cysteine 41 and cysteine 109
Cysteine 158 and cysteine 217
Cysteine 109 and cysteine 91
A redox-regulated disulphide may form between cysteine 245 of IgG H chain and cysteine 235 of IGL@ protein (236 and 213 respectively in this structure).

Details

Redox score ?
94
PDB code
5w08
Structure name
a/texas/50/2012(h3n2) influenza hemagglutinin in complex with k03
Structure deposition date
2017-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
IgG H chain
Peptide B name
IGL@ protein
Peptide A accession
S6C4S0
Peptide B accession
Q6IPQ0
Peptide A residue number
245
Peptide B residue number
235

Ligandability

Cysteine 245 of IgG H chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 235 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 238 of IGH@ protein and cysteine 235 of IGL@ protein (224 and 215 respectively in this structure).

Details

Redox score ?
94
PDB code
5utz
Structure name
human il-2/fab complex
Structure deposition date
2017-02-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
IGH@ protein
Peptide B name
IGL@ protein
Peptide A accession
Q6GMX6
Peptide B accession
Q6IPQ0
Peptide A residue number
238
Peptide B residue number
235

Ligandability

Cysteine 238 of IGH@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 235 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGL@ protein between cysteines 41 and 109 (23 and 88 respectively in this structure).

Details

Redox score ?
79
PDB code
6vtu
Structure name
dh717
Structure deposition date
2020-02-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
95
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IPQ0
Residue number A
41
Residue number B
109
Peptide name
IGL@ protein

Ligandability

Cysteine 41 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 109 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGL@ protein between cysteines 158 and 217 (136 and 195 respectively in this structure).

Details

Redox score ?
79
PDB code
5w0d
Structure name
inferred precursor (uca) of the human antibody lineage k03
Structure deposition date
2017-05-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6IPQ0
Residue number A
158
Residue number B
217
Peptide name
IGL@ protein

Ligandability

Cysteine 158 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGL@ protein between cysteines 109 and 91 (90 and 91 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5w0d
Structure name
inferred precursor (uca) of the human antibody lineage k03
Structure deposition date
2017-05-30
Thiol separation (Å)
8
Half-sphere exposure sum ?
97
Minimum pKa ?
12
% buried
nan
Peptide accession
Q6IPQ0
Residue number A
109
Residue number B
91
Peptide name
IGL@ protein

Ligandability

Cysteine 109 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 in protein B could not be asigned to a Uniprot residue.
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