ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Centromere protein P

Intramolecular
Cysteine 147 and cysteine 204 L
Cysteine 111 and cysteine 147 L
A redox-regulated disulphide may form within Centromere protein P between cysteines 147 and 204.

Details

Redox score ?
73
PDB code
7pb8
Structure name
crystal structure of the cenp-opqur complex
Structure deposition date
2021-07-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
5
% buried
98
Peptide accession
Q6IPU0
Residue number A
147
Residue number B
204
Peptide name
Centromere protein P

Ligandability

Cysteine 147 of Centromere protein P

Cysteine 204 of Centromere protein P

A redox-regulated disulphide may form within Centromere protein P between cysteines 111 and 147. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7xhn
Structure name
structure of human inner kinetochore ccan-dna complex
Structure deposition date
2022-04-09
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
70
Peptide accession
Q6IPU0
Residue number A
111
Residue number B
147
Peptide name
Centromere protein P

Ligandability

Cysteine 111 of Centromere protein P

Cysteine 147 of Centromere protein P

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