a tool for identifying drug-targetable redox-active disulphides

Pleckstrin homology domain-containing family A member 7

Intermolecular

Cysteine 193 and cysteine 193

A redox-regulated disulphide may form between two units of Pleckstrin homology domain-containing family A member 7 at cysteines 193 and 193. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

30

PDB code

Structure name

crystal structure of plekha7 ph domain biding so4

Structure deposition date

2020-10-26

Thiol separation (Å)

9

Half-sphere exposure sum ?

87

Minimum pK_a ?

13

% buried

94

Peptide A name

Pleckstrin homology domain-containing family A member 7

Peptide B name

Pleckstrin homology domain-containing family A member 7

Peptide A accession

Peptide B accession

Peptide A residue number

193

Peptide B residue number

193

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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