ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DENN domain-containing protein 5A

Intramolecular
Cysteine 1028 and cysteine 1044
Cysteine 797 and cysteine 944
Cysteine 978 and cysteine 1002
A redox-regulated disulphide may form within DENN domain-containing protein 5A between cysteines 1028 and 1044 (1004 and 1020 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3cwz
Structure name
structure of rab6(gtp)-r6ip1 complex
Structure deposition date
2008-04-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
42
Peptide accession
Q6PAL8
Residue number A
1028
Residue number B
1044
Peptide name
DENN domain-containing protein 5A

Ligandability

Cysteine 1028 of DENN domain-containing protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1044 of DENN domain-containing protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DENN domain-containing protein 5A between cysteines 797 and 944 (773 and 920 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3cwz
Structure name
structure of rab6(gtp)-r6ip1 complex
Structure deposition date
2008-04-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
12
% buried
95
Peptide accession
Q6PAL8
Residue number A
797
Residue number B
944
Peptide name
DENN domain-containing protein 5A

Ligandability

Cysteine 797 of DENN domain-containing protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 944 of DENN domain-containing protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DENN domain-containing protein 5A between cysteines 978 and 1002 (954 and 978 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3cwz
Structure name
structure of rab6(gtp)-r6ip1 complex
Structure deposition date
2008-04-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
35
Peptide accession
Q6PAL8
Residue number A
978
Residue number B
1002
Peptide name
DENN domain-containing protein 5A

Ligandability

Cysteine 978 of DENN domain-containing protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1002 of DENN domain-containing protein 5A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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