a tool for identifying drug-targetable redox-active disulphides

Splicing regulator SDE2

Intramolecular

Cysteine 406 and cysteine 415 L

A redox-regulated disulphide may form within Splicing regulator SDE2 between cysteines 406 and 415 (32 and 41 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

50

PDB code

Structure name

sde2 sap domain apo structure

Structure deposition date

2021-06-17

Thiol separation (Å)

9

Half-sphere exposure sum ?

47

Minimum pK_a ?

9

% buried

0

Peptide accession

Residue number A

406

Residue number B

415

Peptide name

Splicing regulator SDE2

Ligandability

Cysteine 406 of Splicing regulator SDE2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 415 of Splicing regulator SDE2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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