ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Nipped-B-like protein

Intramolecular
Cysteine 1876 and cysteine 1889
Cysteine 1391 and cysteine 1433
Cysteine 2392 and cysteine 2437
Cysteine 1889 and cysteine 1940
Cysteine 2088 and cysteine 2091
Cysteine 2045 and cysteine 2088
Cysteine 2045 and cysteine 2091
A redox-regulated disulphide may form within Nipped-B-like protein between cysteines 1876 and 1889.

Details

Redox score ?
73
PDB code
6wge
Structure name
cryo-em structure of human cohesin-nipbl-dna complex without stag1
Structure deposition date
2020-04-05
Thiol separation (Å)
5
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
74
Peptide accession
Q6KC79
Residue number A
1876
Residue number B
1889
Peptide name
Nipped-B-like protein

Ligandability

Cysteine 1876 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1889 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nipped-B-like protein between cysteines 1391 and 1433.

Details

Redox score ?
60
PDB code
6wge
Structure name
cryo-em structure of human cohesin-nipbl-dna complex without stag1
Structure deposition date
2020-04-05
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
53
Peptide accession
Q6KC79
Residue number A
1391
Residue number B
1433
Peptide name
Nipped-B-like protein

Ligandability

Cysteine 1391 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1433 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nipped-B-like protein between cysteines 2392 and 2437. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6wg3
Structure name
cryo-em structure of human cohesin-nipbl-dna complex
Structure deposition date
2020-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
66
Peptide accession
Q6KC79
Residue number A
2392
Residue number B
2437
Peptide name
Nipped-B-like protein

Ligandability

Cysteine 2392 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2437 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nipped-B-like protein between cysteines 1889 and 1940. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
6wg3
Structure name
cryo-em structure of human cohesin-nipbl-dna complex
Structure deposition date
2020-04-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
71
Peptide accession
Q6KC79
Residue number A
1889
Residue number B
1940
Peptide name
Nipped-B-like protein

Ligandability

Cysteine 1889 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1940 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nipped-B-like protein between cysteines 2088 and 2091. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6wg3
Structure name
cryo-em structure of human cohesin-nipbl-dna complex
Structure deposition date
2020-04-04
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
90
Peptide accession
Q6KC79
Residue number A
2088
Residue number B
2091
Peptide name
Nipped-B-like protein

Ligandability

Cysteine 2088 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2091 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nipped-B-like protein between cysteines 2045 and 2088. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6wg3
Structure name
cryo-em structure of human cohesin-nipbl-dna complex
Structure deposition date
2020-04-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
74
Peptide accession
Q6KC79
Residue number A
2045
Residue number B
2088
Peptide name
Nipped-B-like protein

Ligandability

Cysteine 2045 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2088 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Nipped-B-like protein between cysteines 2045 and 2091. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6wge
Structure name
cryo-em structure of human cohesin-nipbl-dna complex without stag1
Structure deposition date
2020-04-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
78
Peptide accession
Q6KC79
Residue number A
2045
Residue number B
2091
Peptide name
Nipped-B-like protein

Ligandability

Cysteine 2045 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2091 of Nipped-B-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: