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Methylcytosine dioxygenase TET2

Intramolecular
Cysteine 1133 and cysteine 1135
Cysteine 296 and cysteine 1221
Cysteine 1135 and cysteine 1221
Cysteine 1133 and cysteine 1221
Cysteine 1271 and cysteine 1273
Cysteine 1289 and cysteine 1358
Cysteine 1193 and cysteine 1271
Cysteine 1298 and cysteine 1358
Cysteine 1271 and cysteine 1378
Cysteine 1289 and cysteine 1298
More...
Cysteine 1193 and cysteine 1273
Cysteine 1273 and cysteine 1378
Cysteine 1263 and cysteine 1374
Cysteine 1193 and cysteine 1378
Cysteine 1263 and cysteine 1378
Cysteine 1133 and cysteine 296
A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1133 and 1135.

Details

Redox score ?
91
PDB code
5d9y
Structure name
crystal structure of tet2-5fc complex
Structure deposition date
2015-08-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
34
Minimum pKa ?
5
% buried
0
Peptide accession
Q6N021
Residue number A
1133
Residue number B
1135
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1133 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1135 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 296 and 1221 (1135 and 1221 respectively in this structure).

Details

Redox score ?
89
PDB code
7ne6
Structure name
human tet2 in complex with unfavourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
6
% buried
0
Peptide accession
Q6N021
Residue number A
296
Residue number B
1221
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 296 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1221 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 1135 has been assigned to correct residue.
A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1135 and 1221.

Details

Redox score ?
88
PDB code
5d9y
Structure name
crystal structure of tet2-5fc complex
Structure deposition date
2015-08-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
37
Minimum pKa ?
5
% buried
0
Peptide accession
Q6N021
Residue number A
1135
Residue number B
1221
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1135 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1221 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1133 and 1221.

Details

Redox score ?
84
PDB code
7ne6
Structure name
human tet2 in complex with unfavourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
31
Minimum pKa ?
8
% buried
0
Peptide accession
Q6N021
Residue number A
1133
Residue number B
1221
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1133 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1221 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 1133 has been assigned to correct residue.
A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1271 and 1273.

Details

Redox score ?
76
PDB code
7ne6
Structure name
human tet2 in complex with unfavourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
6
% buried
nan
Peptide accession
Q6N021
Residue number A
1271
Residue number B
1273
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1271 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1273 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1289 and 1358.

Details

Redox score ?
75
PDB code
5deu
Structure name
crystal structure of tet2-5hmc complex
Structure deposition date
2015-08-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
7
% buried
nan
Peptide accession
Q6N021
Residue number A
1289
Residue number B
1358
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1289 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1358 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1193 and 1271.

Details

Redox score ?
73
PDB code
7ne6
Structure name
human tet2 in complex with unfavourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
78
Minimum pKa ?
6
% buried
78
Peptide accession
Q6N021
Residue number A
1193
Residue number B
1271
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1193 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1271 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1298 and 1358.

Details

Redox score ?
71
PDB code
5d9y
Structure name
crystal structure of tet2-5fc complex
Structure deposition date
2015-08-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
96
Peptide accession
Q6N021
Residue number A
1298
Residue number B
1358
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1298 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1358 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1271 and 1378. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
4nm6
Structure name
crystal structure of tet2-dna complex
Structure deposition date
2013-11-14
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
6
% buried
86
Peptide accession
Q6N021
Residue number A
1271
Residue number B
1378
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1271 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1378 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1289 and 1298. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
7ne6
Structure name
human tet2 in complex with unfavourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
19
% buried
nan
Peptide accession
Q6N021
Residue number A
1289
Residue number B
1298
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1289 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1298 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1193 and 1273. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7ne3
Structure name
human tet2 in complex with favourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
19
% buried
nan
Peptide accession
Q6N021
Residue number A
1193
Residue number B
1273
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1193 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1273 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1273 and 1378. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5deu
Structure name
crystal structure of tet2-5hmc complex
Structure deposition date
2015-08-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
16
% buried
nan
Peptide accession
Q6N021
Residue number A
1273
Residue number B
1378
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1273 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1378 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1263 and 1374. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7ne3
Structure name
human tet2 in complex with favourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
11
% buried
100
Peptide accession
Q6N021
Residue number A
1263
Residue number B
1374
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1263 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1374 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1193 and 1378. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7ne6
Structure name
human tet2 in complex with unfavourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
88
Minimum pKa ?
16
% buried
89
Peptide accession
Q6N021
Residue number A
1193
Residue number B
1378
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1193 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1378 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1263 and 1378. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7ne6
Structure name
human tet2 in complex with unfavourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
100
Peptide accession
Q6N021
Residue number A
1263
Residue number B
1378
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1263 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1378 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Methylcytosine dioxygenase TET2 between cysteines 1133 and 296 (1133 and 1135 respectively in this structure).

Details

Redox score ?
nan
PDB code
7ne6
Structure name
human tet2 in complex with unfavourable dna substrate
Structure deposition date
2021-02-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
6
% buried
0
Peptide accession
Q6N021
Residue number A
1133
Residue number B
296
Peptide name
Methylcytosine dioxygenase TET2

Ligandability

Cysteine 1133 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 296 of Methylcytosine dioxygenase TET2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 1133 has been assigned to correct residue.
Uncertain whether structure cysteine 1135 has been assigned to correct residue.
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