ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IGL@ protein

Intramolecular
Cysteine 41 and cysteine 106
Cysteine 156 and cysteine 215
A redox-regulated disulphide may form within IGL@ protein between cysteines 41 and 106 (22 and 90 respectively in this structure).

Details

Redox score ?
80
PDB code
5whj
Structure name
crystal structure of fab fragment of anti-fcrn antibody dx-2507
Structure deposition date
2017-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
91
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NS95
Residue number A
41
Residue number B
106
Peptide name
IGL@ protein

Ligandability

Cysteine 41 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 106 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGL@ protein between cysteines 156 and 215 (138 and 197 respectively in this structure).

Details

Redox score ?
78
PDB code
5whj
Structure name
crystal structure of fab fragment of anti-fcrn antibody dx-2507
Structure deposition date
2017-07-17
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NS95
Residue number A
156
Residue number B
215
Peptide name
IGL@ protein

Ligandability

Cysteine 156 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 215 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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