ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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TRA@ protein

Intramolecular
Cysteine 44 and cysteine 110
Cysteine 155 and cysteine 205
A redox-regulated disulphide may form within TRA@ protein between cysteines 44 and 110 (25 and 92 respectively in this structure).

Details

Redox score ?
81
PDB code
6fr4
Structure name
003 tcr study of cdr loop flexibility
Structure deposition date
2018-02-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NSA1
Residue number A
44
Residue number B
110
Peptide name
TRA@ protein

Ligandability

Cysteine 44 of TRA@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of TRA@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within TRA@ protein between cysteines 155 and 205 (135 and 185 respectively in this structure).

Details

Redox score ?
81
PDB code
6fr4
Structure name
003 tcr study of cdr loop flexibility
Structure deposition date
2018-02-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NSA1
Residue number A
155
Residue number B
205
Peptide name
TRA@ protein

Ligandability

Cysteine 155 of TRA@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of TRA@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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