ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Myogenesis-regulating glycosidase

Intramolecular
Cysteine 125 and cysteine 134
Cysteine 158 and cysteine 284
A redox-regulated disulphide may form within Myogenesis-regulating glycosidase between cysteines 125 and 134.

Details

Redox score ?
85
PDB code
7qqf
Structure name
crystal structure of unliganded myorg
Structure deposition date
2022-01-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NSJ0
Residue number A
125
Residue number B
134
Peptide name
Myogenesis-regulating glycosidase

Ligandability

Cysteine 125 of Myogenesis-regulating glycosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 134 of Myogenesis-regulating glycosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Myogenesis-regulating glycosidase between cysteines 158 and 284.

Details

Redox score ?
80
PDB code
7qqg
Structure name
crystal structure of myorg bound to 1-deoxygalactonojirimycin
Structure deposition date
2022-01-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q6NSJ0
Residue number A
158
Residue number B
284
Peptide name
Myogenesis-regulating glycosidase

Ligandability

Cysteine 158 of Myogenesis-regulating glycosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 284 of Myogenesis-regulating glycosidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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